High Performance Liquid Chromatography:Article Title: Macrocyclic indole derivatives
Article Snippet: Method P7: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, gradient: 0.00-0.50 min 10% B (150 ml/min), 0.50-6.00 min 10-50% B (150 ml/min), 6.00-6.10 min 50-100% B (150 ml/min), 6.10-8.00 min 100% B (150 ml/min), UV-Detection.
Article Title: 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides
Article Snippet: Preparativ HPLC Methods Instrument: pump: Labomatic HD-3000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; eluent; gradient; UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P5: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 35% B (150 ml/min), 0.50-6.00 min 35-100% B (150 mL/min), 6.00-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P4: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P12: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Specific Optial Rotation Methods: Method O1: Instrument: JASCO P2000 Polarimeter; wavelength 589 nm; temperature: 20° C.; integration time 10 s; path length 100 mm.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P8: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: XBridge, RP C18 5 μm, 100×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, gradient: 0.00-2.00 min 10% B (60 ml/min), 2.00-14.00 min 10-50% B (60 ml/min), 14.00-14.10 min 50-100% B (60 ml/min), 14.10-17.00 min 100% B (60 ml/min), UV-Detection.
Article Title: PTEFB inhibiting macrocyclic compounds
Article Snippet: Preparative HPLC Instrument: pump: Labomatic HD-5000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; solvent A: water+0.2 vol-% ammonia (32%), solvent B: acetonitrile; gradient: 0.00-0.50 min 15% B (150 mL/min), 0.50-6.00 min 15-55% B (150 mL/min), 6.00-6.10 min 55-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min); UV-detection (256 nm).
Injection:Article Title: Macrocyclic indole derivatives
Article Snippet: Method P7: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, gradient: 0.00-0.50 min 10% B (150 ml/min), 0.50-6.00 min 10-50% B (150 ml/min), 6.00-6.10 min 50-100% B (150 ml/min), 6.10-8.00 min 100% B (150 ml/min), UV-Detection.
Article Title: 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides
Article Snippet: Preparativ HPLC Methods Instrument: pump: Labomatic HD-3000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; eluent; gradient; UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P5: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 35% B (150 ml/min), 0.50-6.00 min 35-100% B (150 mL/min), 6.00-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P4: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P12: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Specific Optial Rotation Methods: Method O1: Instrument: JASCO P2000 Polarimeter; wavelength 589 nm; temperature: 20° C.; integration time 10 s; path length 100 mm.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P8: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: XBridge, RP C18 5 μm, 100×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, gradient: 0.00-2.00 min 10% B (60 ml/min), 2.00-14.00 min 10-50% B (60 ml/min), 14.00-14.10 min 50-100% B (60 ml/min), 14.10-17.00 min 100% B (60 ml/min), UV-Detection.
Article Title: PTEFB inhibiting macrocyclic compounds
Article Snippet: Preparative HPLC Instrument: pump: Labomatic HD-5000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; solvent A: water+0.2 vol-% ammonia (32%), solvent B: acetonitrile; gradient: 0.00-0.50 min 15% B (150 mL/min), 0.50-6.00 min 15-55% B (150 mL/min), 6.00-6.10 min 55-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min); UV-detection (256 nm).
Solvent:Article Title: Macrocyclic indole derivatives
Article Snippet: Method P7: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, gradient: 0.00-0.50 min 10% B (150 ml/min), 0.50-6.00 min 10-50% B (150 ml/min), 6.00-6.10 min 50-100% B (150 ml/min), 6.10-8.00 min 100% B (150 ml/min), UV-Detection.
Article Title: 3-oxo-6-heteroaryl-2-phenyl-2,3-dihydropyridazine-4-carboxamides
Article Snippet: Preparativ HPLC Methods Instrument: pump: Labomatic HD-3000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; eluent; gradient; UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P5: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 35% B (150 ml/min), 0.50-6.00 min 35-100% B (150 mL/min), 6.00-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P4: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.1 Vol-% formic acid (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P12: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: Chromatorex RP C-18 10 μm, 125×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, Gradient: 0.00-0.50 min 30% B (150 ml/min), 0.50-6.00 min 30-70% B (150 mL/min), 6.00-6.10 min 70-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min), UV-Detection.
Article Title: Macrocyclic indole derivatives
Article Snippet: Specific Optial Rotation Methods: Method O1: Instrument: JASCO P2000 Polarimeter; wavelength 589 nm; temperature: 20° C.; integration time 10 s; path length 100 mm.
Article Title: Macrocyclic indole derivatives
Article Snippet: Method P8: Instrument: Pump: Labomatic HD-5000 or HD-3000, Head HDK 280, low pressure gradient module ND-B1000; Manual injection valve: Rheodyne 3725i038; Detector: Knauer Azura UVD 2.15; Collector: Labomatic Labocol Vario-4000; Column: XBridge, RP C18 5 μm, 100×30 mm; Solvent A: water+0.2 Vol-% ammonia (32%), Solvent B: acetonitrile, gradient: 0.00-2.00 min 10% B (60 ml/min), 2.00-14.00 min 10-50% B (60 ml/min), 14.00-14.10 min 50-100% B (60 ml/min), 14.10-17.00 min 100% B (60 ml/min), UV-Detection.
Article Title: PTEFB inhibiting macrocyclic compounds
Article Snippet: Preparative HPLC Instrument: pump: Labomatic HD-5000, head HDK 280, lowpressure gradient module ND-B1000; manual injection valve: Rheodyne 3725i038; detector: Knauer Azura UVD 2.15; collector: Labomatic Labocol Vario-4000; column: Chromatorex RP C-18 10 μm, 125×30 mm; solvent A: water+0.2 vol-% ammonia (32%), solvent B: acetonitrile; gradient: 0.00-0.50 min 15% B (150 mL/min), 0.50-6.00 min 15-55% B (150 mL/min), 6.00-6.10 min 55-100% B (150 mL/min), 6.10-8.00 min 100% B (150 mL/min); UV-detection (256 nm).
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